Fatal Case of Marrow Aplasia after Treatment with Carbimazole

Fatal marrow aplasia associated with non-A non-B hepatitis.

swellings have not been reported. The condition is a multisystem disease with a mortality rate of up to 63%, death being due to either respiratory failure or the development of a malignant lymphoma.' An immunological basis for the disease has been suggested because of extensive immunological dysfunction found in a recent study of six patients.3 The aetiology is unknown but, interestingly, altho...

Change from propylthiouracil to carbimazole proves fatal.

Recent changes in New Zealand have altered the availability of propylthiouracil. It is no longer a ‘funded’ medication but is only available via an ‘Exceptional Circumstances’ application to the Pharmaceutical Management Agency (PHARMAC). Because of this a number of patients in our practice were changed from propylthiouracil to carbimazole. We report a patient who developed agranulocytosis foll...

Ii. Aplasia of Marrow and Fatal Intoxication in Dogs Produced by Roentgen Radiation of All Bones

Constant findings were obtained in the acute reaction to the specified amount of heavily filtered radiation over the bony skeleton. 1. There develops without warning a short and fatal intoxication on the 8th or 9th day after the exposure to the radiation. 2. A profound leucopenia appears after 5 to 6 days and is maintained in the peripheral blood (200 white blood cells or less per c. mm.) for t...

Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced bone marrow aplasia.

The synthetic cytokine (Synthokine) SC-55494 is a high-affinity interleukin-3 (IL-3) receptor ligand that stimulates greater in vitro multilineage hematopoietic activity than native IL-3, while inducing no significant increase in inflammatory activity relative to native IL-3. The aim of this study was to investigate the in vivo hematopoietic response of rhesus monkeys receiving Synthokine after...

Bone marrow necrosis after treatment with sulphasalazine.